5 edition of Neuropharmacology of Polyamines (Neuroscience Perspectives) found in the catalog.
September 16, 1994
by Academic Press
Written in English
|Contributions||Chris Carter (Editor), Peter Jenner (Series Editor)|
|The Physical Object|
|Number of Pages||336|
Part of the Methods in Molecular Biology™ book series (MIMB, volume 79) Abstract Most cells are able to supplement de novo polyamine synthesis with uptake on specific transport systems, especially in response to stimuli that provoke cell growth or when de novo synthesis is blocked by specific inhibitors, such as D,L -α. Books Advanced Search Amazon Charts Best Sellers & more Top New Releases Deals in Books School Books Textbooks Books Outlet Children's Books Calendars & Diaries Neuropharmacology of Polyamines (Neuroscience Perspectives) by Chris Carter and Peter Jenner | 17 Aug
Looking for a book? Search. Free Downloads Chris Jenner Books. Showing 1 to 27 of 27 results. Fibromyalgia and Myofascial Pain Syndrome. ISBN ISBN 20 Oct FFPMRCA FRCA MB BS DR Chris Jenner Download Fibromyalgia and Myofascial Pain Syndrome by FFPMRCA FRCA MB BS DR Chris Jenner. Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines. J Physiol. Oct 15; (Pt 2)– [PMC free article] Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data. Neuropharmacology.
Polyamines accumulate in high concentrations, both intra- and extracellularly and interestingly, intracellular polyamines appear to exert an inhibitory influence on NMDA receptor channel open probability independently of stoichiometry (Turecek et al. ) while extracellular polyamines positively modulate NMDA receptor activity and these. Abstract. 1. The block by ifenprodil of voltage-activated Ca2+ channels was investigated in intracellular free calcium concentration ([Ca2+]i) evoked by 50 mM K+ (high-[K+]o) in Furaloaded rat hippocampal pyramidal neurones in culture and on currents carried by Ba2+ ions (IBa) through Ca2+ channels in mouse cultured hippocampal neurones under whole-cell voltage-clamp.
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Neuropharmacology of Polyamines' [unknown] on *FREE* shipping on qualifying offers. Neuropharmacology of Polyamines'Author: unknown. Neuropharmacology of polyamines. London ; San Diego: Academic Press, © (OCoLC) Online version: Neuropharmacology of polyamines.
London ; San Diego: Academic Press, Neuropharmacology of Polyamines book (OCoLC) Document Type: Book: All Authors /. Neuropharmacology publishes high quality, original research within the discipline of neuroscience.
The emphasis of Neuropharmacology is on the study and understanding of the actions of known exogenous and endogenous chemical agents on neurobiological processes in the mammalian nervous system. Work with non-mammalian and invertebrate species may be considered in exceptional circumstances.
Polyamines are required for growth in almost all cells. An adequate supply of polyamines is especially important to the gastrointestinal epithelium where 72 h is the length of an average cell's life.
Cell growth (as proliferation) is the basis of the continual renewal of the gastrointestinal epithelium. Polyamine. Polyamines are involved in a variety of plant metabolic processes such as cell division, embryogenesis, reproductive organ development, root growth, tuberization, floral initiation, fruit development, fruit ripening, floral initiation, leaf senescence, and responses to.
We have investigated the effects of polyamine agonists and antagonists on the modulation of the N-Methyl-d-aspartate receptor by glycine using a [3 H]dizocilpine ([3 H]MK) binding assay.
We monitored the non-equilibrium binding of [3 H]dizocilpine in the presence of 5,7-dichlorokynurenate to preclude occupation of the glycine site by endogenous glycine. Neuropharmacology is the scientific study of the effects of drugs on the nervous system.
Its primary focus is the actions of medications for psychiatric and neurologic disorders as well as those of drugs of abuse. Neuropharmacology also uses drugs as tools to form a better understanding of normal nervous system functioning.
Pergamon Tetrahedron Letters 39 () TETRAHEDRON LETTERS Practical Synthesis of Unsymmetrical Polyamine Amides Ian S. Blagbrough* and Andrew J. Geall Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
Received 16 October ; revised 27 October ; accepted 31 October Abstract: Desymmetrisation of readily available symmetrical polyamines. Abstract. The extent of ionization of the polyamines is an important factor in their interactions with cellular components.
The pK a is the pH at which a functional group is 50% ionized. For compounds such as polyamines with more than one ionizable center (atom or functional group), there is a pK a value for each center of ionization. This chapter describes the pK a values for each amine group. Naturally occurring diamines and polyamines have attracted considerable attention in synthetic organic chemistry due to their interesting biological activities, 1 potential pharmacological applications, 2 and asymmetric catalysis.
3 However, their synthetic use is quite limited mainly due to lack of efficient methods for monofunctionalization, although this problem has been averted by. Abstract. Although receiving little attention in biochemical and physiological textbooks, the polyamines have a long history and have accumulated a considerable.
Neuropharmacology of antiepileptic drugs. Paul B. Pritchard. Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Charleston, SC, USA. Search for more papers by this author.
Book Editor(s): Robert P. Lisak MD FAAN FRCP(E) FANA. Parker Webber Chair in Neurology, Professor of Neurology. This book is the transcription of the Fifth Conference on Neuropharmacology, which was held inand is essentially a stenographic report of the comments of the twenty-eight participants.
There is a brief introduction, followed by four conferences, at which the following subjects were discussed: "Amine Metabolism and Its Pharmacological. Author of Ground Zero, Denver International Airport, Neuropharmacology of polyamines, Air, The x-files, Impact of electronic and multi-media journals on scholarly communications, Using the newpaper, Struct Programm into Ansi C Pb.
Polyamine biosynthesis. Polyamines are small, naturally occurring, polycationic alkylamines that are essential for normal cell growth and development in eukaryotes (Refs 1, 2).Both their charge distribution and flexibility allow polyamines to bind to various anionic macromolecules including DNA, RNA, proteins, and acidic phospholipids (Refs 3, 4).The vital importance of polyamines for normal.
Synthetic polyamines. Several synthetic polyamines are used in chemical industry and the research laboratory. They are mainly of interest as additives to motor oil and as co-reactants (hardeners) with epoxy resins.
Many synthetic polyamines feature NCH 2 CH 2 N linkages. Diethylenetriamine, abbreviated dien or DETA, (H 2 N-CH 2 CH 2-NH-CH 2 CH 2-NH related permethylated.
Preclinical studies further suggest that inhibitory modulators that specifically reduce the co-agonist effects of polyamines on NMDARs are potential non-toxic medications. Using agmatine as a lead compound, over novel compounds based loosely on this structure were synthesized using feedback from a molecular screen.
There is much evidence to support the idea that polyamines may play a multifaceted detrimental role following ischemia reperfusion. Due to the deficit of knowledge about their physiology in the CNS, the link between ischemia-induced alterations in polyamine metabolism.
CiteScore: ℹ CiteScore: CiteScore measures the average citations received per peer-reviewed document published in this title. CiteScore values are based on citation counts in a range of four years (e.g.
) to peer-reviewed documents (articles, reviews, conference papers, data papers and book chapters) published in the same four calendar years, divided by the number of.
COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.
The polyamines spermidine and spermine, and their diamine precursor, putrescine, are aliphatic cations essential for normal cell physiology and growth.
Cancer cells, especially highly metastatic tumours, require elevated polyamine levels and characteristically express abnormally high activity of ODC (ornithine decarboxylase), the initial enzyme.Altogether, the results demonstrate that Mygalin has an anticonvulsant activity that may be an important tool in the study of prospection of therapeutics in epilepsy neuropharmacology.
Keywords: Anticonvulsant, MK, Morris Water Maze, Mygalin, NMDA, Open Field, polyamine, PTZ.Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse.
There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading.